Synaptotagmin 2 Is the Fast Ca 2+ Sensor at a Central Inhibitory Synapse
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منابع مشابه
Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse
GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca2+ sensor of exocytosis at GABAergic basket cell (BC) to Purkinje cell (PC) synapses in cerebellum. Immunolabeling suggested that BC term...
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Evoked and spontaneous neurotransmitter release mechanisms share similar components. Synaptotagmin-1 (Syt-1) plays a central role in evoked neurotransmitter release as a Ca sensor. Syt-1 has also been implicated in the regulation of spontaneous release. A recent study perfomed on central synapses confirms the role of Syt-1 in spontaneous release, as a Ca sensor, a fusion clamp and an inhibitor ...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2016.12.067